Progesterone to Estrogen Ratio Calculator

The progesterone to estrogen ratio calculator calculates the Pg/E2 ratio as a marker of female sexual function health. Usually, Women should fall between 100 to 500 when they are in good health. A larger ratio could signify progesterone dominance. If it’s lower, estrogen dominance is more probable.

What’s the progesterone to estrogen ratio calculator?

The progesterone to estrogen ratio calculator converts progesterone and estradiol units and predicts the value of a parameter used to measure hormone imbalance. The progesterone to estrogen ratio, often known as the Pg/E2 or P/E2 ratio, is essential in determining the female hormone balance and predicting the outcome of in vitro fertilization. Be aware that estradiol concentration is typically measured in pg/mL while progesterone concentration is typically found in ng/mL, requiring conversion to ng/mL for the former.

Estradiol (E2) is a female sex hormone that is a member of the estrogen family. Estriol (E3) and Estrone (E1) are two other essential estrogens–  however, the progesterone to estradiol ratio estimation uses the concentration of estradiol because it is the most potent and frequently measured hormone.

Before we go into how to calculate your progesterone-to-estrogen ratio, let’s first take a look at what progesterone and estrogen are.

Progesterone and Estrogen

Chemical messengers that regulate your body’s numerous organs and systems are abundant in the human body. Our body contains several hormone-like substances. Your metabolism, growth, and other systems can all be impacted by their levels and presence.

The two most crucial hormones for female bodies are progesterone and estrogen. These steroid hormones cause the body’s distinct female traits. The female reproductive system’s health is maintained by the ovaries, a pair of ova-producing structures that create egg cells. The ovaries are an endocrine gland that secretes hormones essential for normal reproductive development and fertility in addition to their function in the production of ova. These hormones include progesterone and estrogen.

What is estrogen?

The steroid hormone estrogen sends physiological signals to various body systems and organs. For each physiological system and organ, these messages are different. The uterus, for example, receives instructions from estrogen to expand and replace the lining that was shed during the previous menstrual cycle.

All human bodies should manufacture estrogen in some capacity, although the precise forms produced will vary depending on your sex.

  • Female bodies generally produce Estrone, estradiol, and estriol.
  • Male bodies commonly produce Estrone and estradiol.

Estrone, estradiol, and estriol are the three main estrogens that naturally occur in women.

  1. Estradiol (E2): Estradiol predominates in terms of absolute serum levels and estrogenic activity during reproductive years.
  2. Estrone (E1): Estrone is the primary circulating estrogen during menopause.
  3. Estriol (E3): In terms of serum levels, estriol dominates among circulating estrogens during pregnancy.

Although estriol is the most prevalent estrogen, it is also the weakest; estradiol is the strongest and has an estimated 80-fold higher potency than estriol.

The ovaries are the primary source of estrogen in female bodies. Normal estrogen production in guys occurs in fatty tissues. Additionally, it can be produced from extra testosterone by enzymes.

Although estrogen serves various purposes, its crucial part in forming and developing female reproductive organs is what makes it most well-known. It aids in menstrual cycle maintenance and makes it easier for the uterus to prepare for both expected and actual pregnancy.

All human bodies also require estrogen to maintain healthy bone development and health, promote cognitive function, and control mood.

What is progesterone?

Progesterone is a hormone generated mainly by the ovaries– but it is also produced in lower amounts by the adrenal glands and the placenta of pregnant women. The hormone aids in controlling menstruation gets the body ready for pregnancy and nourishes the uterine environment to support the implantation of the fertilized egg and placenta growth.

Additionally, progesterone levels differ from person to person. Progesterone is frequently associated with its effects and presence on female bodies, much like estrogen, yet it can also be found in male and intersex bodies.

Increased progesterone levels instruct the female body to thicken the uterine lining in preparation for receiving a fertilized egg. During gestation, if an egg is fertilized, the body continues to generate progesterone to nourish the growing fetus. The preparation of the breasts for milk production also requires progesterone.

Estradiol and progesterone unit conversion

The hormone concentrations are typically expressed in different units. Estradiol is often measured in picograms per milliliter (pg/mL) or picomoles per liter (pmol/L), while

Progesterone is most frequently measured in ng/mL (nanogram per liter) or nmol/L (nanomole per liter).

The two must be expressed in the same units in order to be compared.

  • Progesterone: 1 ng/mL = 3.180547 nmol/L
  • Estradiol: 1 pg/mL = 3.6713 pmol/L

The value is then multiplied by 1000 to convert from ng/mL to pg/mL or divided by 1000 to convert from pg/mL to ng/mL.

Progesterone to estradiol ratio estimation

The estimate of the P/E2 ratio is simple once the hormone concentrations are converted to the same unit of measurement:

ratio = progesterone / estradiol


Should the levels of estrogen and progesterone be the same?

Both hormones are essential to a woman’s health, but they must be balanced. Inadequate progesterone levels are problematic on their own, and estrogen doesn’t work as well when progesterone levels are low.

What are the symptoms of high estrogen?

In women, high estrogen levels can result in symptoms like heavy or irregular periods, weight gain, exhaustion, and uterine fibroids. They can result in infertility, breast tissue growth, and trouble attaining or keeping an erection in men.

What signs indicate high progesterone?

Anxiety and irritability, bloating, breast swelling and soreness, sadness, exhaustion, and weight gain are among the symptoms of elevated progesterone.


The progesterone to estrogen ratio is a key factor in predicting the outcome of in vitro fertilization and determining the female hormone balance. Estrogen and progesterone are thought to be crucial for female sexual reproduction. But they also control how all bodies’ organ systems, including those of the bones and the brain, develop. The most excellent advice for taking hormones of any kind safely is to strictly adhere to your doctor’s instructions and maintain open communication about any alterations to your body.

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